Shuri was the Princess of Wakanda, daughter of T'Chaka and Ramonda, sister of T'Challa, and the leader of the Wakandan Design Group. An innovator responsible for creating much of Wakanda's modern technology, she is also known for designing the current generation Panther Habits. After her brother's coronation, Shuri assisted him and the Dora Milaje in tracking down Ulysses Klaue, only to be forced to flee the Golden City as Erik Killmonger overthrew the throne, eventually returning to reclaim Wakanda. Later, Shuri was assigned by T'Challa to delete HYDRA programming from Bucky Barnes' mind.
A couple of years later, she was tasked by her brother and the Avengers in removing the Mind Stone from Vision's head to have Wanda Maximoff destroy it as the android was under threat from Thanos. She was soon compromised by Corvus Glaive, who ambushed her lab and quickly defeated Shuri. Later, Shuri was among the many who died when Thanos completed the Infinity Gauntlet and wiped out half the life in the universe.