Karnak Mander-Azur is the second son of an Inhuman priest and philosopher named Mander and an ocean biologist named Azur. They sent their first son, Triton, into the Terrigen Mist when he was an infant, rendering him incapable of functioning outside an aquatic environment. Thus, they pleaded with the Genetic Council to raise Karnak without Terrigen mutation. Karnak was enrolled in his father's religious seminary in the Tower of Wisdom, where he trained in various physical and mental disciplines until he was eighteen years old;meanwhile, at some point Azur died in a mysterious undersea mishap. Karnak also fathered a son with an unrevealed woman named Leer at an unknown period of time.